Streptozotocin induces Type 1 diabetes by destruction of beta cells. Nicotinamide is given along with STZ to prevent complete destruction of beta cells and produces Type 2 diabetes

Hello Sir, ya though this is a way ..i want to know any other way of induction of type 2 diabetes without STZ.

Hi Sandeep Kumar Swain

Apart from STZ model, alloxan for rat type 2 diabetes typically ranges from 120 to 140 mg/kg of body weight, administered intraperitoneally (IP).

Please find the references attached.

1. Article The effects of dosage and the routes of administrations of s...

2. Article Alloxan-induced diabetes, a common model for evaluating the ...

Thanks,

Hi Samir, Thansk for your suggestion, but i am looking for something without any chemical induction, specificaslly STZ and Alloxan.

streptozotocin and nicotinamide induced model........it is the best

dose...stz(55 to 65 mg/kg) and nta(110 to 120mg/kg)