Except STZ and High fat diet induction model, what esle best model is availbale for induction of Type II diabetes in Rat.
Streptozotocin induces Type 1 diabetes by destruction of beta cells. Nicotinamide is given along with STZ to prevent complete destruction of beta cells and produces Type 2 diabetes
Hello Sir, ya though this is a way ..i want to know any other way of induction of type 2 diabetes without STZ.
Hi Sandeep Kumar Swain
Apart from STZ model, alloxan for rat type 2 diabetes typically ranges from 120 to 140 mg/kg of body weight, administered intraperitoneally (IP).
Please find the references attached.
1. Article The effects of dosage and the routes of administrations of s...
2. Article Alloxan-induced diabetes, a common model for evaluating the ...
Thanks,
Hi Samir, Thansk for your suggestion, but i am looking for something without any chemical induction, specificaslly STZ and Alloxan.
streptozotocin and nicotinamide induced model........it is the best
dose...stz(55 to 65 mg/kg) and nta(110 to 120mg/kg)
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