Mimitochondrial fission is generally regarded as getting rid of bad mitochondria, perhaps the increased fission is trying to get rid of poor mitochondria and what is the purpose of reducing mitochondrial division in neurodegenerative diseases
Hi Ramesh,
Excessive mitochondrial fission (as happens in a high number of neurodegenerative diseases) produces ROS (Qi, X., et al., A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J Cell Sci, 2013; Yu, T., J.L. Robotham, and Y. Yoon, Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci U S A, 2006), which is extremelly hurmful for the cell. By avoiding excessive fission, ROS release by the mitochondria is reduced and cell toxicity is diminished.
Hi Ramesh,
Excessive mitochondrial fission (as happens in a high number of neurodegenerative diseases) produces ROS (Qi, X., et al., A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J Cell Sci, 2013; Yu, T., J.L. Robotham, and Y. Yoon, Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci U S A, 2006), which is extremelly hurmful for the cell. By avoiding excessive fission, ROS release by the mitochondria is reduced and cell toxicity is diminished.
Hello Ramesh,
the review in the attachment is an excellent introduction on the relevance of mitochondrial fission in neurodegeneration. Although there are newer articles, this one still provides a wealth of useful information.
Cheers, Christian
Article Mitochondrial fragmentation in neurodegeneration
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