In clinical practice I observe combining intravenous furosemide with torsemide. This is in order to force diuresis in patients with severe oedema (20-kg water retention).
Is there any rationale to combine this two loop diuretics?
Please let me know if this reference/site is helpful to you.
Article Combination of Loop Diuretics With Thiazide-Type Diuretics i...
Dennis
Dennis Mazur
It is better to combine two different classes of diuretic, like a loop and thiazide or a loop and acetazolamide.
Thank you all.
I have neither found any literature support to combine the two loop diuretics. That is true that pharmacology of torsemide is not equal to that of furosemide (e.g. better profile of torsemide towards RAAS - see Buggey et al. 2015 Article A reappraisal of loop diuretic choice in heart failure patients
), but in my opinion in does not support such a combination therapy.Any other points of view?
i confirm the other answers, there is no benefit in combining two loop diuretics.
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