Quinones are recognized as pan assay interference compounds, so my doubt is: does quinones interfere with MTT assay? Since most quinones undergo redox cycles is it possible that MTT assay results could be false positives?
Dear Marcos,
Quinones can interfere with the determination of a compound by MTT assay since the are reactive and give positive control when using MTT assay. For more information regarding this topic, please see the following publications:
https://books.google.ps/books?id=xRflBwAAQBAJ&pg=PA226&lpg=PA226&dq=Quinones+and+MTT+assay&source=bl&ots=KC_oE34cgv&sig=Kk_4cW2i5_m4c5K8gvbcJ6PayIk&hl=en&sa=X&ved=0ahUKEwj0gubKtMnLAhWJB5oKHQWxBZ0Q6AEINDAD#v=onepage&q=Quinones%20and%20MTT%20assay&f=false
https://www.uclouvain.be/cps/ucl/doc/ir-ldri/images/molecules-19-00726.pdf
Hoping this will be helpful,
Rafik
- Badges
- Science topic
- Similar topics
- Medicine
- Disease
- Infectious Diseases