What role do the body microbiota play in augmenting/neutralizing infection intensity in patients suffering from COVID-19? Do SARS-CoV-2 negate the competition from other viral and bacterial strains already present in the patient's body and vice versa? Is there a link between mild to moderate versus severe symptom development among people who have contracted the virus and the presence of specific microbial load in them, apart from their own physiology and genetics? Has there been any research on the possible effect of other influenza virus sub types (mostly B) on SARS-CoV-2? How much does the presence of a diverse microflora influence the onset of cytokine storm in case of infection by a foreign pathogen?
Please have a look at this useful link.
https://www.frontiersin.org/articles/10.3389/fmicb.2020.01302/full
It is quite possible that gut dysbiosis may have influence on the clinical manifestation in Covid-19. Research may be conducted to look at the effect of Covid-19 on the gut microbiota profile and vice versa. It would be interesting to dissect the role of not only bacteria but other microorganisms such as fungi and phages that form a very niche ecosystem in the intestine in Covid-19. Finally, the role of lung microbiota may also be investigated.
Ref:
Article Gut microbiota and Covid-19- possible link and implications
You may follow the link below:
https://medium.com/microbial-instincts/how-covid-19-gut-microbiota-lung-immunity-and-probiotics-interact-7b7cd665b529
Hello Dr. Harasit Kumar Paul ,
You have touched on a chord in your response as the role of phages in competing or even inhibiting or at least delaying symptom onset by SARS-CoV-2 was one of my intended targets to initiate the particular discussion.
Thank you for the article.
Regards,
Dr. Abhishek Mukherjee
Article Main Clinical Features of COVID-19 and Potential Prognostic ...
These articles may be of interest regarding this topic:
1. Article Alterations in Gut Microbiota of Patients With COVID-19 Duri...
2. Article Alterations in Fecal Fungal Microbiome of Patients With COVI...
3. Article Systemic inflammatory response and thrombosis due to alterat...
4. Preprint INTESTINAL DYSBIOSIS IN COVID-19
Thank you Dr. Muhammad Yousuf . The article is quite helpful.
Regards,
There are also a lot of other factors to which we are exposed (e.g. drugs or excipients) capable of altering the viral load:
Article A Panel of Broad-Spectrum Antivirals in Topical Ophthalmic M...
As a teroria it is fascinating. But it should be verified with solid data ..
You may follow the link below:
Article ACE2 imbalance as a key player for the poor outcomes in COVI...
Sofia Viana
Thank you for your response. The article you recommended has already been consulted.
Regards
Please check one more slide with the statistical information: after 6 months of pandemic statistics of covid-19 cases have been showing fantastic stability in being largely confined to the 30-50 degree belt (92%-97% of the world's totals).
The microbiota consisting of beneficial microbes are often the first line of defense. Normally, the respiratory tract microbiota (both upper and lower) are often the first to fight against intruders i.e coronavirus. However, their potency is dependent on the types, nature and composition of the beneficial microbes present in the mucus surface. Also, the immune system of an individual plays a pivotal role. Once the immune system and the beneficial microbes consisting the microbiota are potent, they can successfully mitigate and to some extend destroy the intruding virus. Or perhaps down-regulate the expression of coronavirus virulence. That is why we have asymptomatic COVID-19 individuals. Their immune system and microbiota were able to successfully mitigate the virus
Because of its intrinsic duality, the innate human microbiota is a double-edged sword for health. We need it to train our innate and adaptive immunity, and provide us with the essential nutrients:
Article Commentary: Reconciling Hygiene and Cleanliness: A New Persp...
But the overgrown of any of the microbial strain at any site of our body, especially the respiratory tract, is the source of severe inflammation, which is the main trigger for cytokine storm. So better keep them with us, but restrict their population as low as possible by the xenophagy in the epithelial cells by daily restrictive eating and short term fasting.
