Hello,
I observed negative nonlinear effect during development of enantioselective reaction and %ee product vs %ee ligand curve has local minimum: there is aprox. 10% ee of product when the %ee of ligand is 10 and 65%.
It might as well be an experimental error but I suspected that there might be two different pathways involved, could this explain the minimum? It seems that literature examples dont have any local minimum if the nonlinear effect is observed.
thanks
Dear Michal Kriegelstein thank you for your interesting technical question. For more genera information please have a look at the following potentially useful article:
Nonlinear Effects in Asymmetric Synthesis and Stereoselective Reactions: Ten Years of Investigation
http://portal.uni-freiburg.de/plattner/dateien/seminarreactivity/enantioselcatal
This article is freely available as public full text. Also please see the attached closely related article.