Poly-genic risk score have recently been an area area of interest for disease risk stratification, Geneticists have developed multiple PGRs for multiple diseases based on GWAS studies, my question is, from a genetic concept , you are allowed to use PGRs meant for a specific disease to predict another disease just because you think there some overlap between the SNPs associated between each disease based on previous GWAS? is it problematic from Genetic perspective, even if it's really working??

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