Ongoing with my previous discussion topic I have found data linking Cystatin C being associated with neurological conditions like Alzheimer's disease and cardiovascular disease apart from being in use marker of renal disease.

Like deficiency of cystatin C is associated with aneurysmal disease .

Reference: Lindholt JS et al. Cystatin C deficiency is associated with the progression of small abdominal aortic aneurysms. Br J Surg. 2001 Nov;88(11):1472-5.

Similarly, cystatin C deficiency is associated with atherosclerosis. This probably results from its non-availability to inhibit the action of lysosomal and other proteases.

Reference: Abisi S et al. Cysteine protease activity in the wall of abdominal aortic aneurysms. J Vasc Surg. 2007 Dec;46(6):1260-6.

However, the levels of cystatin C were found to be raised in myocardial infarction, stroke and risk of death.

Anyway my reasons to adding this another episode of Cystatin C is to learn more about the biomarker behavior, especially once the marker is confounded by atherosclerotic and other neurological conditions which normally happen so in geriatric population.

Any comments will help and needed especially from you practice guidelines. .