Please, can anybody explain how the band gap energy of CuO nanoparticles related with cytotoxicity?
Dear S. P. Goutam, there are two things which we have to consider while correlating bandgap energy with cytotoxicity.
First is the room temperature photo-induced activation of the material. It directly depends upon Bandgap energy of the nano-material. As we know, at nanoscale, it can be tailored. So alteration in bandgap energies will boost the chance to excitation of surface atoms (on grain boundaries) of the nano-material. it will generate ROS cycle. This ROS can be lethal but to find this we have to look for second point.
Secondly, ROS cycle can be generative or scavenging. If the system in which nano-material is working is full of ROS (variable pH) than nano-material it self have the capability of tuning ROS and they will act as bio-compatible, like in case of plant tissue. But in case of animal tissue like cancer cell, contrasting behavior have been observed. Here will also have to think about the REDOX potential of the nano-material (means valency power). Some time due to synthetic chemical capping agent around nano-materials, they can generate lethal ROS which will cause ROS induced cell death.
So, dear S. P. Goutam, Bandgap energy, photoexcitation of surface atoms and ROS generation are related with each other.
Some material are cytotoxic when having lower bandgap energies and some are having higher bandgap energies. it depends upon physio-chemical properties of the precursor material.
Best Wishes.
Hello,
Please, can you tell me what the value of Bg of CuO nanoparticle that you meaning??
If the Bg of any semiconductor in ranged 1.1 to about 4 and sometime 5 eV, this will behave as photocatalyst (i.e it is absorbed UV or Visible light) and lead a e-h pairs which produce series of redox reaction that may be reacted with other compound and generated a toxicity effect.
Really, there are some attempts to correlate bandgap and toxicity of metal oxide nanoparticles, see enclosed example. However, copper oxide falls out of the general pattern due to its solubility and toxicity of Cu(II) ions: “While CuO and ZnO generated oxidative stress and acute pulmonary inflammation that is not predicted by Ec levels..”
Article Use of Metal Oxide Nanoparticle Band Gap To Develop a Predic...
It is a good question. I agree with Professor Alexander B. Shcherbakov.
All the best,
M-
Dear S. P. Goutam, there are two things which we have to consider while correlating bandgap energy with cytotoxicity.
First is the room temperature photo-induced activation of the material. It directly depends upon Bandgap energy of the nano-material. As we know, at nanoscale, it can be tailored. So alteration in bandgap energies will boost the chance to excitation of surface atoms (on grain boundaries) of the nano-material. it will generate ROS cycle. This ROS can be lethal but to find this we have to look for second point.
Secondly, ROS cycle can be generative or scavenging. If the system in which nano-material is working is full of ROS (variable pH) than nano-material it self have the capability of tuning ROS and they will act as bio-compatible, like in case of plant tissue. But in case of animal tissue like cancer cell, contrasting behavior have been observed. Here will also have to think about the REDOX potential of the nano-material (means valency power). Some time due to synthetic chemical capping agent around nano-materials, they can generate lethal ROS which will cause ROS induced cell death.
So, dear S. P. Goutam, Bandgap energy, photoexcitation of surface atoms and ROS generation are related with each other.
Some material are cytotoxic when having lower bandgap energies and some are having higher bandgap energies. it depends upon physio-chemical properties of the precursor material.
Best Wishes.
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