Dear Hervé Besançon ,

I think the following might come close to what you are looking for:

https://heliquest.ipmc.cnrs.fr/

This program predicts potential (helical) lipid binding regions in proteins and peptides. According to:

https://heliquest.ipmc.cnrs.fr/HelpProcedure.htm

you can come up with the so-called lipid binding discrimination factor that predicts regions with a potential lipid binding ability (and thereby the protein lipid binding potential). See for an example:

Article The prediction of novel multiple lipid-binding regions in pr...

you can expand this feature with the so-called Heliquest based Eisenberg plot method:

Article New User-Friendly Approach to Obtain an Eisenberg Plot and I...

That enables you to predict whether the protein is a membrane protein, a protein with a surface binding ability or a globular protein with lipid binding ability. A relatively new class of (globular) proteins with lipid binding ability is the amphitropic protein family:

Article Identification and in silico analysis of helical lipid bindi...

Hope this helps you a step further.

Best regards.

This is exactly what I had in mind.

Thanks a lot for the great ressources.

Best regards.