For example,
1) Rapamycin can augment autophagy by inhibiting PI3K/AKT/mTOR signaling; Uro-A acts as an inhibitor of Akt phosphorylation, thus reinforcing autophagy via the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR signaling pathway.
2) Studies have shown that IGF-I is one of the important positive regulators of skeletal muscle growth, which controls the anabolism of skeletal muscle mass through the IGF-1/PI3K/Akt/mTOR signaling pathway. But GDF-8 can inhibit the activation of Akt, thereby inhibiting the PI3K / Akt / mTOR signaling pathway and affecting the function of skeletal muscle.
Tomas Koltai
It depends on what you want to achieve.
If you require biosynthesis you stimulate the pathway
If you treat a tumor you inhibit it.
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