A year ago I asked if the cytosolic pH (pHcyto) was equal to the pH in the mitochondrial intermembrane space (pHims). One person responded, and we agreed that the outer mitochondrial membrane is no barrier to the movement of protons so pHcyto = pHims. But two people do not make a scientific consensus.
In recent decades it has become clear that the outer mitochondrial membrane has a vital role in programmed cell death, but this does not address its normal physiological role.
Questions for discussion:
- Is there a membrane potential across the OUTER mitochondrial membrane?
- Is the OMM VDAC channel ever closed?
- What transmembrane proteins (besides VDAC) reside in the OMM?
- Several enzymes localize to the cytosolic face of the OMM. Examples: MAO, KMO. Do you know of others? Is there a teleological reason for these localizations?
- What else does the OMM do?
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