Sangita Chanda The research topic is quite relevant, given the global rise of antimicrobial resistance. But it may be refined to ensure novelty and broader impact.

For examle; "Molecular and Phenotypic Characterization of MBL-Producing Klebsiella pneumoniae: A Multi-Omics Approach to Antibiotic Resistance"

Here you can integrate whole-genome sequencing or metagenomics, proteomics, and MALDI-TOF MS for a comprehensive resistance profiling.

Combine MALDI-TOF with molecular techniques (PCR, CRISPR-based detection) for improved specificity and sensitivity.

Also, exploring how MBL-producing K. pneumoniae affects treatment efficacy in patients can make your research more translational.

All the best

thank u so much mam Athira V. Anand

Optimization of a Low-Cost MALDI-TOF MS Protocol for Rapid Detection of Co-Produced MBL and ESBL Enzymes in Clinical Isolates of Klebsiella pneumoniae Athira V. Anand is it a good one for PhD need ur suggestion