I wish to know if peritoneal injection of MSU in mice is proper study model for gout? Most common are air pouch model or ankle inflammation. Is peritoneal based gout model are clinically relevant?.
I don't think so. Considering this disease, gout occurs predominantly when MSU crystals activate joint cells, causing arthritis. In this case, the injection of crystals into joint cavities is more appropriate. On the other hand, other compartments are useful to identify mechanisms of MSU-associated inflammation, as air pouch and peritoneal cavities.