Hi V H Krishna Prasad

Depends on the application.

However, the fact is:

if you look at the list of FDA approved medicines, you will clearly see that "liposomes" are leading by far ahead of other drug delivery systems.

Thank you for your reply M. R. Mozafari . Could you please add your insights on the use of PEG coated liposomes conjugated piperlongumine for treatment of oral cancer?

Thank you again M. R. Mozafari

Have a look at following passages from our recent publications V H Krishna Prasad :

4.2. Nanoliposomes with Surface-bound Nanoparticles

One of the limitations of liposomes is their propensity to aggregate, fuse, and create larger vesicles. This phenomenon especially occurs with nanoliposomes smaller than 100 nm. This significant size increase due to fusion limits the ability of the lipid vesicles to deliver therapeutic agents to the target cells. Using a protective coating like polyethylene glycol (PEG) is a popular strategy to stabilize liposomes against fusion. Another strategy is using charged nanoparticles ab- sorbed into the head groups of surface lipids without any non-specific interaction.

...

Source:

Mehrarya, M., Gharehchelou, B., Kabarkouhi, Z., Ataei, S., Esfahani, F. N., Wintrasiri, M. N., & Mozafari, M. R. (2022). Functionalized Nanostructured Bioactive Carriers: Nanoliposomes, Quantum Dots, Tocosome, and Theranostic Approach. Current Drug Delivery, 19(10), 1001-1011.

and:

5.2. Long circulating stealth liposomes and nanoliposomes

Intravenously injected conventional vesicles are mostly eliminated from the blood circulation, after opsonization, by the cells of the immune system that are mainly present in the liver and spleen [60]. Opsonization is the process by which liposomes are marked for ingestion and elimination by the macrophages and phagocytes. Inclusion of certain polymers (e.g., polyethylene glycol (PEG), polyhydroxyethyl L-asparagine (PHEA), etc.), or incorporation of glycolipids (e.g., monosialoganglioside) into liposomes and nanoliposomes, prevent opsonization and result in sterically stabilized vesicles [61-63].

...

Source:

Mozafari, M. R., Torkaman, S., Karamouzian, F. M., Rasti, B., & Baral, B. (2021). Antimicrobial applications of nanoliposome encapsulated silver nanoparticles: A potential strategy to overcome bacterial resistance. Current Nanoscience, 17(1), 26-40.

PEG

Lipid polymer hybrid nanoparticles Xiaojing Liu