Bacterial resistance became a medical emergency because the use and abuse of antibiotics has become prevalent. For instance, in the US, around 35,000 die from drug-resistant diseases and at least 2.8 million people become infected with the disease. Furthermore, the coexistence of inadequate new antibiotics and increasing antibiotic resistance raised a big problem as only 8 out of 51 newly developed antibiotics can treat antibiotic resistance (Cui et al., 2021). With this, new strategies to treat diseases are greatly needed. Potential drugs for drug resistant bacteria were cultivated and studied. Out of the three drugs, I want to know how Odilorhabdins (ODLs) become a promising candidate for new drug development thoroughly by their:
- Source
- Mode of action
- Activity against what microorganism
Source:
Cui X, Lü Y, Yue C. Development and Research Progress of Anti-Drug Resistant Bacteria Drugs. Infect Drug Resist. 2021;14:5575-5593 https://doi.org/10.2147/IDR.S338987
Hello, as you already mentioned the antibiotic resistance is really issue which we can not avoid as adaptation possibility of microorganisms will always find a way to survive against any drug here only short time frame is needed for them to develop the new capabilities.
By this way we making more survivable types of microorganisms against whom in one day we cant find any chemical drug. It cane also from today medical approaches no one really testing the antibiotic profile of patient if he is not in critical stage and always new antibiotics are in recipes. We need to understand that in human the bacterial cells much more than mammalian and in this big diversity of microorganisms the major player is microbial antagonism. To not cause any resistance we need to develop the areas of probiotics, prebiotics and bacterial phage therapy.
Odilorhabdins (ODLs) are a class of antibiotics that were discovered by screening soil samples for antimicrobial activity against drug-resistant bacteria. ODLs were found to be effective against a wide range of Gram-negative bacteria, including multidrug-resistant strains such as Pseudomonas aeruginosa and Acinetobacter baumannii.
One reason why ODLs became a promising candidate for new drug development is their unique mechanism of action. ODLs target the ribosome, a cellular component essential for protein synthesis in bacteria, and bind to a different site than other antibiotics. This makes ODLs less likely to be affected by existing mechanisms of resistance, such as efflux pumps or target modification.
In addition, ODLs have shown promising results in preclinical studies. In vitro studies have shown that ODLs are highly effective against a wide range of Gram-negative bacteria, including multidrug-resistant strains. Animal studies have also shown that ODLs can effectively treat infections caused by drug-resistant bacteria without causing significant toxicity.
Finally, the chemical structure of ODLs is amenable to modification, which could potentially improve their efficacy or reduce toxicity. This makes ODLs an attractive candidate for further development and optimization as a new antibiotic.
Overall, the discovery of ODLs as a promising candidate for new drug development against drug-resistant bacteria was based on their unique mechanism of action, broad-spectrum activity, and promising results in preclinical studies. Further research and development will be needed to determine their clinical potential and safety for use in humans.
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