Interestingly, peroxynitrite, a potent oxidant derived from the chemical reaction of superoxide radicals with nitric oxide, has been linked to pain; hence, reducing peroxynitrite may be an effective way to decrease pain associated with oxidative stress/inflammation-induced arthritis. In fact, another paper discussed different types of pain and the role played by superoxide and peroxynitrite but proposes targeting peroxynitrite over that of superoxide because of the physiological signaling of superoxide. “It may be PN [peroxynitrite] is a more attractive target, in that unlike SO [superoxide] it has no currently known beneficial role.” Since hydrogen preferentially scavenges hydroxyl radicals and peroxynitrite over that of superoxide and hydrogen peroxide, it may be beneficial in pain relief.