There were indications a few years back that sildenafil (Cialis) may prevent or reverse peripheral neuropathy. I hope to learn about any ongoing research on this.
Dear Ernest Rogers
Yes, experimental data show that treatment of diabetic peripheral neuropathy with a potent PDE5 inhibitor, sildenafil, improves blood supply to the sciatic nerve. Patients with diabetic peripheral neuropathy who are treated for erectile dysfunction with sildenafil have reduced symptoms of neuropathy.
Article Sildenafil Ameliorates Long Term Peripheral Neuropathy in Ty...
There is no evidence that confirms ANY KIND OF POSITIVE EFFECT of sildenalfil ("Viagra" or similar - "FDE5 inhibitors" -) in Peripheral Neuropathy ... MORE ON THE CONTRARY!, Since its NEGATIVE EFFECTS in Neuropathy have been demonstrated Non-Arteritic Anterior Ischemic Optic - NAAIO-, as shown - in addition to clinical experience - by various Articles and their Bibliographies (HV Danesh-Meyer and LA Levin: "Review of recent evidence on FDE5 inhibitors and the risk of non-arteritic anterior ischemic optic neuropathy -NAAIO- "Br J Ophthalmol 2007; 91: 1551–1555; R. Mukamal:" Study Sizes Up Viagra's Vision Problem "Edited by A. Delfaro Apr. 20, 2020; C. Karaarslan - World Eye Hospital, Adana, Turkey- 02/07/2020, https: //doi.org/10.3389/ fneur. 2020.00067 "Ocular side effects of sildenafil that persist beyond 24 h: a series of cases" Neurol.; VC Morales and YC Parra: "STUDY DESCRIPTION OF ADVERSE REACTIONS WITH SILDENAFIL REPO RECEIVED TO THE WORLD PHARMACOVIGILANCE PROGRAM OF THE WHO FROM THE YEAR 1998 TO SEPTEMBER 2019 ". Faculty of Health Sciences; Bogota; 2020 ... etc ...) as well as the WHO itself warns, along with many other adverse side effects.
Some authors indicate that in the Peripheral Neuropathies generated by Insuline Dependent Diabetes, certain positive evidences do appear ... but the World Scientific Community is quite skeptical about this and, ABOVE ALL, questions that the "positive" results - doubtful - deserve it is worth taking the risks of this type of drug (it would be like "killing flies with cannon shots" and would violate the universal bioethical principle of "primum non nocere" or PRINCIPLE OF BENEFICIENCY).
I described a serious of cases in 2006 and a protocol reached the final stages but Lilly were already involved in LUTS and Pulm Hypertension, so they reasoned that the patent would expire before all possible indications could be explore Sairam et al also presented cases of improvement PVD in diabetes is related to vascular ischaemia and PDE5Is have been clearly shown to improve endothelial function, insulin sensitivity , flow mediated dilatation and inflammatory markers. As most men with PVD will have a degree of ED, they are already indicated Tadalafil 5mg with a half live of 17 hours plus and daily use licence is clearly the drug of choice. Even 15 years later I continue to see marked clinical improvements. It is also effective in Raynauds through similar mechanisms