Can anyone suggest about the 3 D brain on chip development for CNS regeneration study..What are the cell types which we should mainly focus or cell lines. Else directly neural progenitor cell will be more feasible to study.
Anand N Rao
Hello,
One accepted cell type for regeneration studies are adult DRG neurons. You can utilize this cell type in combination with microfluidic chambers to perform axotomy studies (see attached pub; Section K).
Hope this helps,
Anand
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Sutarmo Vincentius Setiadji
DRG cells are peripheral nerve fbers which their myelins are made from Schwann cell. Their axons can regenerate. In the brain, for example the optic nerve, their myelins are from oligodendrocyte cells. I had read that their axons of these kind of nerve fibers can not regenerate.
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