Generally, mTOR is described to function as a lysosomal-associated nutrient sensor which stimulates cell proliferation. When mTOR is inactivated via nutrient-starvation or AMPK activation, it falls off lysosomes into the cytosol.
However, does anyone know if mTOR can remain active in the cytosol, or if its localisation always dictates the activation stage?
Thank you,
Dear Johannes!
You look also at this pulication, please:
Article Where is mTOR and what is it doing there?
Table 1.
Lysosome localization of TORC1
Table 2.
Localization of TORC1 to other organelles
Localization of mTORC1
When lysosomotropic agents are used such as astemizole or itraconazole, mTOR is detached from the lysosomal membrane and is inactivated. This is one of the mechanisms by which lysosomotropic agents have anti-cancer effects. Therefore, I presume that mTOR is functional only while attached to the lysosomal membrane.
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