Hi,
Dear researchers,
spike protein and nucleocapsid of SARS-CoV-2, which preferred to be targeted by drugs? Why?
I think it is the spike protein. Nevertheless, a lot of mutations have occurred on the spike protein. I will suggest you search literature in order to select a target. Pubmed can come in handy.
Dear researchers, I'm currently doing an ensemble-based virtual screening. May I asked How many pico/nanoseconds should run for Molecular dynamics simulation of a protein? Do the production...
14 November 2022 4,338 3 View
Dear researchers, My research is to determine which peptides pose antiviral activity. I used Acrylamide: Bis-Acrylamide Ratio 13:1 as this is ideal for Peptide separation and Color Marker...
18 March 2021 4,119 4 View
Dear researchers, Any recommendation on FREE online Webserver/ Software For metabolomic approaches and toxicity prediction for dermal ? Is better if enclosed with guidance on how to interpret...
16 March 2021 7,959 1 View
Dear researchers, I obtained a toxicity model report of goniothalamin. How to interpret data from Protox II? 1) What is meaning the red and green coloured region ? 2) What is mean active and...
16 March 2021 6,745 1 View
Dear researchers, I am new to Molecular dynamics. I would like to do protein-ligand molecular dynamics by using gromacs. My ligand is goniothalamin and my protein is PDB id 2c56 protein. I...
14 March 2021 1,921 11 View
Dear researchers, Do anyone know what is the recipe of destaining and staining solution for silver staining ? May I get the simple method for doing this ? My laboratory do not have any silver...
06 October 2020 7,846 6 View
Dear researchers, May I know since my protein bands cannot be seen clearly, can I done negative staining on SDS-PAGE before carry out In gel trypsination ? Thank you.
29 September 2020 4,871 3 View
Dear researchers, I have a problem on SDS-PAGE. My protein concentration of plant protein extract is about 0.7032 µg/µL. After that, I mix 28µL of sample with 7µL of 4x sample buffer to load...
27 September 2020 8,886 10 View
I have virus (viral hemorrhagic septicemia virus) in suspension and the experiment will not involve cells. What level of TCID50 is preferred?
11 August 2024 3,115 1 View
I am experimenting with cancer and non-cancer cells in a 12-well plate for 4 days with a seeding density 1*10^4/well, however, I noticed that the control group growth rate slows down on D3. Should...
07 August 2024 2,283 2 View
Hi, I know that low molecular weight (MW) molecules generally tend to have higher mobility, while high molecular weight molecules tend to have lower mobility. However, in my experimental...
06 August 2024 1,495 2 View
kindly reply me. Thanking you in advance.
05 August 2024 7,727 4 View
I work on MCF7 cell cell for anticaner purpose and I wa to do drug preperation the drug ( secondary metabolites extracted from Aspergillus) My question which solvent is better with these secodary...
03 August 2024 4,725 2 View
Is it possible to conduct a molecular dynamics simulation to see the effects of a specific carbohydrate on the structure of lipids (e.g., micelle structure)? I am a beginner in this field and plan...
03 August 2024 3,371 3 View
Hello, if you made a transwell assay where you incubate the cells with a nanoparticle-encapsulated drug and considering that in the oposite compartment you'll have both the free and encapsulte...
03 August 2024 2,730 1 View
I am using a windows system, what software I should use for hydration shell analysis with molecular dynamics?
02 August 2024 3,143 4 View
Molecular docking software/ websites?
02 August 2024 8,704 7 View
Dear All Gromacs User I would like to restart MD without using checkpint .cpt files? I heard there is a way for acheiveing this. Any input and sugegstions are most welcome. Thanking You Budheswar
29 July 2024 3,084 8 View