Hello,

Do you believe that a microrna which target a mRNA in a situation of cell differentiation will still target this mRNA in a tumoral situation let say.

In other words does a mir targets a mRNA just if this one is expressed or is the cell state important? Is a microrna which targets a mRNA in tissue A, still targets this mRNA in tissue B?

Are there factors that inders mir action (stability, expression ect...).

The purpose of this question regards the large amount of research focussing on tumor and mir regulation, can this work be pulled together with others area of mir reseach? True mir target are still scarce aside this kind of research .

This question might be a bit naive but will greatly help me.

thanks In advance for your answers

ND