Please does anyone have any experience on melanomacrophage centers in fish kidney? In particular about the initial phases in which they are recognizable (with little melanin pigment), their immunophenotypic characteristics, and their location with respect to the microanatomy of the kidney?
I am a pathologist of human diseases and for years I studied a pathological cell with leiomuscolar phenotype and co-expression of some melanocytic markers.
Thank you very much, unfortunately I can access only at the abstract of the work that you've reported,
good job, Maurizio
Here some articles concerning MMCs in fish, I hope they'll give you further information.
Kind regards
Frauke
http://onlinelibrary.wiley.com/doi/10.1111/j.1439-0264.2005.00669_87.x/abstract
http://informahealthcare.com/doi/abs/10.1081/IPH-51766
http://informahealthcare.com/doi/abs/10.1080/08923970701812290
http://link.springer.com/article/10.1007/BF00303074
Dear Pea,
Here is one article below.
www.ncbi.nlm.nih.gov/pubmed/14575368
All the best
Ercument Genc
Dear Maurizio,
Melanomacrophages (MMP) are known to be involved in defense mechanisms against various microbes (Roberts, 1975). In our study on Viral Nervous Necrosis (VNN) we observed focal aggregates of melanomacrophage-like cells containing viral particles scattered throughout the brain and retina in affected juvenile suvived VNN.
Also, Melanomacrophage center belongs to fish innate immune system. in fact, Melanomacrophages (MMP) are macrophages that contain pigment in fish infectious diseases.
Let me present you some related article as follows:
http://www.scielo.br/pdf/ni/v5n3/a13v5n3.pdf
http://cdn.intechopen.com/pdfs/41563/InTech-Fish_cytokines_and_immune_response.pdf
http://www.int-res.com/articles/dao2002/50/d050p161.pdf
Kindly regard
Jalil
The Melano -macrophages centers appeared when fish ages or exposed to stress.This is it's life history.All adult fish as tilapia have MMc in kidney and spleen.
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