Mechanism of sulfonamide drugs

More Alex Boye's questions See All

Merging profiles after change in name due to marriage?

Hello- I have two profiles in ResearchGate. One under my married name of Kristina Secnik and one under my married name of Kristina S Boye or Kristina Boye. How do I merge my publications so that...

29 July 2024 4,426 1 View

What are the frameworks or methodologies to examine written academic ELF?

What should be the frameworks or methodologies to examine written academic ELF? I want to explore the linguistic features of written ELF in research articles.

23 July 2024 4,800 1 View

How to analyse response rates of a questionnaire?

I have developed a questionnaire. I want to try and analyse question drop-off. There is a clear negative correlation between question number and percentage of respondents who answered that...

07 July 2024 9,435 1 View

Can anybody recognize the virus on potato plants?

Infected potato plant was negative for PVY, PVX, PVM, PVS. What can it be?

19 June 2024 6,739 3 View

Is the preference for more established researchers by reputable academic journals leading to infrequent publishing of Bachelor's degree theses?

I think, for a long time, there has been a tendency for journals to favour work from more established researchers or institutions, thus potentially overlooking quality undergraduate research. This...

16 June 2024 6,801 3 View

How do you generate recursive proofs over time series data?

What are the recommended recursive algorithms to generate proofs of time variant and time invariant properties from a time series data. Approaches like recursive statistical tests, symbolic time...

08 June 2024 4,449 0 View

What is the ratio between the density of the bacterial population during anaerobic and aerobic growth of one species?

What is the relationship between the maximal density of a bacterial population during anaerobic and aerobic growth for a specific species - a facultative anaerobe?

01 June 2024 4,950 4 View

Why do Spanish slugs (Arion vulgaris) prefer to feed on the most poisonous or spicy plants?

Spanish slugs choose to feed on some of the most poisonous and spicy plants. Do they become toxic to potential predators due to this? Are there any publications available on this topic?

28 May 2024 3,929 0 View

How build Forest plot in STATA?

(STATA) Hello everybody. I would like to build a Forest Plot graph that includes all this information from the table. I am unable to build the commands to include this information in the chart....

11 May 2024 6,944 6 View

Does air plasma become optically thick at presssures of about hundred bar?

Is there any experimental or theoretical or theoretical knowledge about the optical depth (may be, for different parts of spectrum) of air plasma at pressures about 100 atmospheres?

19 April 2024 5,539 0 View

Is changing the medium during the experiment overestimate the results?

I am experimenting with cancer and non-cancer cells in a 12-well plate for 4 days with a seeding density 1*10^4/well, however, I noticed that the control group growth rate slows down on D3. Should...

07 August 2024 2,283 2 View

Why does my protein refolded to beta sheet during thermal denaturation analysis?

Hi! So i attempted to understand a novel protein behavior towards heat application by analyzing its secondary structure change. I subjected the protein to a thermal denaturation analysis using...

06 August 2024 1,989 3 View

Which solvent is better to dissolve with secondary metabolites extracted from fungi?

I work on MCF7 cell cell for anticaner purpose and I wa to do drug preperation the drug ( secondary metabolites extracted from Aspergillus) My question which solvent is better with these secodary...

03 August 2024 4,725 2 View

Can i quantify a nanoparticle encapsulated in cell culture medium by hplc?

Hello, if you made a transwell assay where you incubate the cells with a nanoparticle-encapsulated drug and considering that in the oposite compartment you'll have both the free and encapsulte...

03 August 2024 2,730 1 View

Could someone explain the basics of working with enzymes?

I'm interested in learning about enzyme usage. Could someone explain the basics of working with enzymes? I understand they're different from standard chemicals, but I'm uncertain about the...

01 August 2024 5,460 5 View

What are some diseases that are caused by overactivity of enzymes?

I want to choose a resarch topic regarding enzyme inhibition. So I did my research and found out most of the diseases that originate from enzymes were actually caused by the "deficiency" of...

30 July 2024 2,483 5 View

Is it possible to dock more than one drug in the same active site or pocket of a protein to study synergistic/antagonistic/additive properties?

I wanted to know whether we can observe the synergistic/antagonistic/additive properties of combinations or mixtures of compounds through docking analysis. But during docking preparation any...

28 July 2024 7,413 6 View

How to maintain the drug concentration in cell culture study for long term?

I am working in the filed of long acting drugs with Nano formulation. I want to study the efficacy of my formulation in 2D cell cultures while this required media change on every two days. In such...

24 July 2024 8,696 0 View

I have two problems: 1) the enzyme is not immobilizing efficiently into the MOF material.. 2) the MOF itself has peak on 400nm by using p-NPA test.?

I am working on carbonic anhydrase immobilization into MOFs. I am facing problems with low enzyme loading.. The other issue is that when using p-NPA activity test to detect the activity of the...

20 July 2024 1,440 3 View

How can I determine if a drug binds to a ribosome using a Cryo-EM map?

Hello, I am searching for the binding position of a drug in a ribosome, based on previous work indicating it binds there. The resolution of the ribosome-drug Cryo-EM map is around 2.5 Å. I've been...

19 July 2024 2,155 0 View

Li Hsu

As I know, it binds to the active site of the synthetase.

Mariana Emilia Cozzolino

Sulfonamides are structural analogues of PABA that act as competitive inhibitors of the enzime.

Engelbert Buxbaum

Actually, sulphonamides are pro-drugs, in the body they are converted to sulphanilamide, those act as Mariana Emilia Cozzolino explained.