Heavy metals through different mechanisms produces organ specific toxicity. Can any one help in identifying exact mechanism of metal induced toxicity. (metals of importance, Cd, Pb, Hg, Zn, Cu, and metalloids: Arsenic).
Please kindly find the attached file:
Abstract
Concentrations of various metals are elevated above background levels in several intertidal areas along the Tanzanian coasts. However, there is little available information concerning the toxicity of these metals and how the uptake of these metals by bioindicators are influenced by external factors, such as heavy rains and increased coastal eutrophication, which tend to fluctuate. The present study focused on the uptake and toxicity of Cu and Zn in two common macroalgal species, Padina gymnospora (Phaeophyta) and Ulva reticulata (Chlorophyta). Laboratory studies were performed where metal content, growth (DGR), maximal quantum yields (Fv/Fm) and protein expression patterns (in Ulva) were measured as a response to exposure to Cu and Zn. The levels of metals accumulated in algal tissues correlated well to exposure concentrations and the longer the exposure time, the greater the uptake. However, an increased nutrient load (tested on Padina) or dilution of the seawater (tested on Ulva) affected both uptake of metals and their toxic effects. Here, DGR was more affected than Fv/Fm, suggesting DGR to be the more sensitive indicator of Cu and Zn toxicity. As shown by 2-D gel electrophoresis, more than ten proteins were up-regulated in U. reticulata after being exposed to Cu (1 μg/L), while at higher concentrations (10 and 100 μg/L) of Cu numerous proteins were down-regulated. P. gymnospora was also used as a bioindicator to monitor long-term (1994–2005) and seasonal in-year variations in heavy metal concentrations in the Zanzibar Channel. No clear overall trends were revealed, but analysis of the combined dataset clearly pinpointed the most contaminated sites. It was concluded that seasonal and long-term variations, as well as environmental conditions need to be taken into consideration when using macroalgae as bioindicators.
The next paper focused on :The Effects of Heavy Metals on Aquatic Animals and its mechanism , hope it can help
Although the toxic effects of metals depend on the forms and route of exposure, interruptions of intracellular homeostasis include demage to lipids, protins, enzymes and DNA via the production of free radicals. Heavy metals can cause malfunctioning of cellular processes via displacement of essential metals from their respective sites. Oxidative deterioration of biological macromolecules has been found to be primarily due to binding of metals to DNA and nuclear proteins . For more details Https://res.mdpi.com
Int. J. Mol. Sci. 2015, 16, 29592 - 29630
My interest is in Arsenic carcinogenesis which appears to be methylation of epigenetic DNA + interference with DNA repair molecules such as PARP.
There is a LOT of Open Access stuff out there on this very topic. Unless you have a specific toxic event in mind related to a specific metal.that is not well documented.
Perhaps start at the USEPA website or ATSDRR website.
You will get some details here -
Article Characterization of heavy metal pollution in an anthropogeni...
Please go through the following RG links.
Article Toxicity, mechanism and health effects of some heavy metals
Chapter Mechanism and Health Effects of Heavy Metal Toxicity in Humans
Here is our chapter on Heavy Metal Toxicity in Humans:
MEDTOX TEXTBOOK: TOXICITY OF HEAVY METALS AND RELATED COMPOUNDS: Chapter 67; ORDOG
- November 2019
- In book: MEDICAL TOXICOLOGY: DIAGNOSIS AND TREATMENT OF HUMAN POISONING.
- Chapter: 67
- Publisher: WILLIAMS AND WILKINS: BALTIMORE, MARYLAND, USA.
- Projects:
- Medical Toxicology: Heavy Metal Toxicity
- Preprint Updates
- Gunshot and Stab Wound Trauma
- Medical Toxicology: General
- 📷Gary Joseph Ordog
- 📷Jonathan Wasserberger
- Heavy metal Toxicity in Humans; on RG:
- Badges
- Science topic
- Similar topics
- Biological Science
- Anatomy
- Tissue