I suggest reading the recent paper 

MJHID Educational Clinical Cases

Anemia in the elderly: not always what it seems.

Marco Cerrano, Elena Crisà, Valentina Giai, Mario Boccadoro, Dario Ferrero | DOI: 10.4084/mjhid.2016.017 free online http://mjhid.org/index.php/mjhid/article/view/2016.017 

and Importance of Classical Morphology in the Diagnosis of Myelodysplastic Syndrome

Rosangela Invernizzi, Federica Quaglia and Matteo Giovanni Della Porta

Mediterr J Hematol Infect Dis 2015, 7(1): e2015035,

DOI 10.4084/MJHID.2015.035 http://mjhid.org/index.php/mjhid/article/view/2015.035

Hello, 

You can take a look at this 2012 article by Dr. Steensma, entitled ''Dysplasia has a differential diagnosis: Distinguishing Genuine Myelodysplastic Syndromes (MDS) From Mimics, Imitators, Copycats and Impostors''. You can find the .pdf file on Researchgate. 

Hope this helps. 

Dear colleague,

I personally have seen changes in bone marrow morphology in lymphoma patients prior to any chemo. Mostly, I saw changes in eritroblasts such as binuclear cell morphology, or mitotic figures. Sometimes I saw micromegakaryocytes or pseudo-Gaucher cells. This is rare events. The origin of this changes is unknown to me. My own speculations may be that malignant cells and their microenvironment may produce some cytokines, or substances that disturb regular hematopoiesis. Of course, this need to be evaluated through serious investigations. 

Dear Ivan,

Your right path in this investigation, if you analysis selected cytokines it gives answer in this marrow micro environmental changes link on blood cells formation defect.