So i have this intriguing idea why dont we make hdl and inject to the patients not in a regular basis, but it will be just as dialysis for cholesterol. Of course it will be taking iv, but actually taking iv saline is like taking water in egypt so why dont we make it more benificial and add hdl to it
Where I live, most people would prefer to swallow a statin pill every day rather than be hooked up to an IV drip or get an injection.
Yes ofcourse, but i read or in way i studied the hdl has an anti inflammatory, antithrombotic, endothilial protective function and even antioxidant properties, and lets say that we wont give it all dyslipedic patient but to those at more risk like diabetes(with insuline injection if you want), but just lets ask it in another way, will it help, will high hdl help, will help in those have athroscleisosis, who are suspected to have stroke (and i know that there is that clot tgat need to be lyised,) but will hdl just dilated or in a way help,?
For the purpose of this discussion, it would help to know about how long HDL remains in the circulation. If you could inject it once a month by bolus injection, people at very high risk might accept it as a prophylaxis. If it has to be done every day, there would be much lower acceptance. If it requires a long IV infusion, acceptance would be even lower, as a chronic treatment.
According to this paper, the half life is a day or less.
Article High-Density Lipoproteins (HDL) - Nature's Multi-Functional ...
Dear Sandrew Raafat
As I understand your question, you wish to suggest using HDL for patients with dyslipidemia, with the ultimate aim to reduce atherosclerosis and prevent the related cardiovascular disease (CVD) risk.
HDL's ability to reduce atherosclerotic plaque depends largely upon its capacity to remove cholesterol from the plaques in addition to several other properties that you have listed above.
The manufactured (recombinant) HDL has shown promise in experimental conditions and animal studies. However, its efficacy in humans is yet to be tested. Even other HDL-elevating therapies have not shown much effect due to the HDL remodeling that occurs in dyslipidemic individuals.
However, it appears that recombinant HDL has the potential to become an important arm of future combination therapies aimed at the reduction of atherosclerotic plaque and CVD risk.
References
1. Ibanez B, Giannarelli C, Cimmino G, et al. Recombinant HDL(Milano) exerts greater anti-inflammatory and plaque stabilizing properties than HDL (wild-type). Atherosclerosis. 2012;220:72-7.
2. Ben-Aicha S, Casaní L, Muñoz-García N, et al. HDL (High-Density Lipoprotein) Remodeling and Magnetic Resonance Imaging-Assessed Atherosclerotic Plaque Burden: Study in a Preclinical Experimental Model. Arterioscler Thromb Vasc Biol. 2020;40:2481-2493.