Catalase exhibits susbtrate feed back inhibition and various reports suggest antioxidant imbalance as well as incaresed levels of H2O2 and TNF in vitiligo both in circulation as well as in the skin microenvironment in pateints with vitiligo.TNF induces ROS production in in vitro cultured melanocytes.
Low levels of catalase in vitiligo pateints in thus but obvious and are also our lab findings.