11 November 2010 1 8K Report

Over 600 genes have been implicated in schizophrenia, subscribing to the idea of "multiple genes of small effect". These genes can be related to each other and together etch out signalling networks that are very relevant to the disease, as can be seen at http://www.polygenicpathways.co.uk/keggszgenes.htm

Pathway analysis of GWAS studies is very much in vogue and this type of analysis can be very useful in deciphering the genetic jumble.

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