If someone supplements himself with zinc at a daily dose of 11 mg, does he need to watch out for his dietary sources for zinc content? Or this no upper tolerable with regard to dietary sources? I.E, if someone ingest 11 mg of zinc (supplement form) along with other zinc rich food, will he suffer adverse effects or not?
Average Requirements (ARs) for dietary zinc necessary to meet physiological requirements were estimated using saturation response modelling, taking into account the inhibitory effect of dietary phytate on zinc absorption. Average Requirements range from 6.2 to 10.2 mg/day for women with a reference weight of 58.5 kg and from 7.5 to 12.7 mg/day for men with a reference weight of 68.1 kg (EFSA).
See link: https://www.efsa.europa.eu/en/efsajournal/pub/3844
Zinc is a requirement for multiple enzymatic functions within body.A balance is needed and both excess and deficiency is non-desirable.
Nihada Ahmetovic has explained it well in terms of bodily needs
regards
Dear@Mostafa
Here are some references mentioning zinc associated side effects:
Chapter Neurotoxicity of Zinc
Article Zinc: An underappreciated modulatory factor of brain function
Article Zinc: The Brain's Dark Horse
These articles mainly focus on zinc associated toxicity specifically on brain where a delicate balance of these cations is actually needed.
I hope this helps
Regards
This cartoon also explains the side effects due to zinc excess and deficincy
Plenty of zinc can limit the absorption of copper, leading to copper deficiency in the body. According to the University of Maryland Medical Center, very high doses can reduce immunity, especially in older people, and may increase the level of bad cholesterol in the blood. High doses of zinc may also cause dizziness, fatigue, loss of muscle control, anemia, sweating, hallucinations and nausea.
The maximum amount of daily zinc consumption recommended for adults is 40 mg per day.
https://vkm.no/download/18.645b840415d03a2fe8f26465/1499330020541/db963cd632.pdf
Zinc toxicity:
Article Zinc Toxicity
Article Toxic Effects Associated With Consumption of Zinc
Article Excessive Oral Zinc Supplementation
Article Toxic Effects Associated With Consumption of Zinc
Only exposure to high doses has toxic effects, making acute zinc intoxication a rare event and dangerous for heath.
Zinc toxicity is a medical condition involving an overdose on, or toxic overexposure to, zinc. Such toxicity levels have been seen to occur at ingestion of greater than 225 mg of zinc [unreliable medical source?] Excessive absorption of zinc can suppress copper and iron absorption. The free zinc ion in solution is highly toxic to bacteria, plants, invertebrates, and even vertebrate fish.[ Zinc is an essential trace metal with very low toxicity in humans.
Any intake of zinc supplement must to consider the actual zinc serum level and from this very point the food diet of the patient and other metabolic and clinical outcomes are ocurring in the place. THe MDI is not the number one priority, in that case.
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