Is there any relation between colchicine ( for FMF long term) and lung cancer,
Colchicine has been tested in cancer as a therapeutic drug in 1945 (Ludford, R. J. (1945). Colchicine in the experimental chemotherapy of cancer.). Since then it has been demonstrated that the anti-tubulin action of colchicine which impedes the prosecution of mitosis in metaphase stage may be useful for the treatment of cancer. Due to its toxicity, colchicine has been replaced as an antitubulin agent by taxanes and other antitubulines in the last 20 years. (Zhou, J., & Giannakakou, P. (2005). Targeting microtubules for cancer chemotherapy. Current Medicinal Chemistry-Anti-Cancer Agents, 5(1), 65-71.)
Since the new antitubuline agents like docetacel and paclitaxel entered oncological practice, there was no place for colchicine further development.
Answering your question, colchicine may be used at the experimental level, against lung cancer, but I do not think it will be really useful in the clinical setting.
Clinically acceptable doses of colchicine were tested on hepatocarcinoma cells with interesting results (Lin, Z. Y., Wu, C. C., Chuang, Y. H., & Chuang, W. L. (2013). Anti-cancer mechanisms of clinically acceptable colchicine concentrations on hepatocellular carcinoma. Life sciences, 93(8), 323-328.).
Dear Professor Houda Kawas,
Please have a look at this researchgate link.
https://www.researchgate.net/publication/294257665_Colchicine_induces_autophagy_and_senescence_in_lung_cancer_cells_at_clinically_admissible_concentration_potential_use_of_colchicine_in_combination_with_autophagy_inhibitor_in_cancer_therapy
Good luck
Article Colchicine induces autophagy and senescence in lung cancer c...
Thanks a lot dear colleagues to add your answers and be cooperative. Regards
Please refer following article:
Tumor Biology 37 (8), 10653-10664, 2016
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