Merck and the Merck Manuals

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Hi Mostafa,

I think it would be a great challenge to predict when or even if an adverse reaction will occur. However, the investigator's brochure (IB) or the summary of product characteristics (SmPC) would be potential sources of useful information on this.

Regards,

Hi Mostafa,

There currently does not exist any compendium that collates the detailed timeline or timeframe for development of adverse reactions for individual medication.

For individual drugs, you may wish to consider the individual drug information leaflet which can be found: https://www.medicines.org.uk/emc

Specifically for liver related toxicity, i personally find this resource by NIH useful. https://livertox.nih.gov/ It nicely summarizes information from literature pertaining to timeframe, details of case reports for different liver related toxicity for individual medication

Alternatively, if you are just looking for brief summary in terms of timeline for adverse reactions, the in-depth tab under micromedex has a brief summary of certain drug related adverse reactions. However, a subscription is required for access to this information.

Hope it helps

Regards,

Ben