Hi all,
I am wondering if anyeone of you can help me to quantify/assess the dysbiosis using some kind of ranking or by a scale! or quantitative interpretation. Yes, we can argue that change in microbial community can be estimated but how one can define the cutoff for this change to regard it as a dysbiosis! What could be the strict criteria of assessment?
Thanks
Hello Muhammad,
You can use shannon diversity as a measure.
As observed in many studies, healthy microbial community is stable and composition is evenly distributed, leading to higher shannon diversity. In case of dysbiosis, where only few microbes dominate the microbial community, the shannon is expected to go down.
So, personally I feel shannon diversity index can be a good quantitative measure for dysbiosis.
I hope this helps.
Anubhav
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