I got one deletion of single base in a particular gene which looks to be a frameshift deletion. Are there any server or software which can predict the effect of this deletion on the protein.
Thanks in advance.
I know only about PROVEAN (http://provean.jcvi.org/seq_submit.php). You can choose to submit your job via web-server or download standalone app.
There also is Mutalyzer:
https://mutalyzer.nl/check?name=NM_000492.3%3Ac.2051_2052delinsG
It predicts the change on protein level, given a DNA change. It also provides the correct description of the variant on DNA and Protein level, but it does not (yet) predict the effect on the protein function.
Perhaps you could use Mutalyzer to predict the protein sequences, and copy/paste those into PROVEAN.
I recommend CodonCode Aligner (http://www.codoncode.com/aligner/). get a reference sequence from NCBI and align the contigs (your sequence). finally select the option "find indels" in codoncode aligner.
easy to use and highly recommended.
good luck!
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