Hi,
I was just wondering how tight junctions contribute to the development of diseases and if there is any known connection between Claudin 6 expression in developmental programming and/or the development of metabolic diseases?
Any thoughts/ comments?
Thanks,
Pooja.
After tight junction are broken, any molecule is able to cross to lamina propria in the small intestine. If the person is prone to autoimmunity or other diseases, large exogen molecules are bound to receptors in antigen-presenting cells and a response is started.
Oligodendrocyte-specific protein (OSP/claudin-11) is a four transmembrane protein concentrated in central nervous system myelin. Recent evidence has emerged suggesting that OSP/claudin-11 is involved in membrane interactions at tight junctions and with the extracellular matrix. OSP/claudin-11 seems to modulate proliferation and migration of oligodendrocytes presumably through these interactions. Furthermore, evidence is presented implicating OSP/claudin-11 as an autoantigen in the development of autoimmune demyelinating disease.
J Neurosci Res. 2000 Mar 15;59(6):706-11.
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