It is well known that CD14 used to differentiate human monocytes from macrophages. But mouse macrophages may not follow the same expression. So I was wondering, could we use CD14 as marker of mouse macrophages? dose it follow the same pattern as human CD14? high in monocytes and low in macrophages?
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Guillaume Alexandre
Sorry but i think CD14 is not good for what you want to do. To be short, read this paper ''Time to abandon dogma: CD14 is expressed by non-myeloid lineage cells'' by H. Jersmann. @+
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Claudia Jakubzick
Actually CD14 can not distinguish between human monocytes and human macrophages. You can use Cd64+Mertk to distinguish monocytes from macrophages in mice. Or high levels of F480.
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