Our team is currently developing a medical device to treat diabetes. To test its effectiveness, we have planned an experiment using rats as subjects. The experiment involves inserting the device into the rat's body using a microneedle and keeping it in place for two weeks. In preparation for this, we shaved the rats using clippers and depilatory creams. However, the device has fallen off due to the regrowth of the rats' hair. Can you assist us in finding a solution to keep the device securely attached throughout the experiment?
We are investigating methods to control hair growth and promote hair loss in mice used for experiments. One of the methods we are considering is inducing hair loss through chemical means using DPCP, among other substances. However, we are encountering difficulty in finding reliable references for this method. Do you happen to have any information on this topic?
Lee Da-In
I see. Can you describe your device's overall shape or size, including the microneedle? Also, why must the hair be removed if it is fixed to the body by microneedle insertion?
Sung-Jun Lee
We have designed the device to be round, with a confirmed cross-section size of approximately 2.36x3.54 inches. To ensure continuous monitoring, the device must be attached to the body's surface for two weeks using a medical adhesive patch placed on its bottom.
Initially, we encountered a problem when the adhesive patch lost its fixing power and fell off the skin after hair regrowth, causing the equipment to fail. Therefore, we made a cap with several holes drilled on the side to fit the development equipment. We covered and sutured the cap after attaching the equipment for higher fixation. However, as the hair grows, the cap pushes the gear out, making it difficult to achieve perfect attachment.
Another option for permanent hair removal might be using a laser. Laser hair removal involves directing a laser beam at the hair follicles to inhibit future hair growth. However, laser hair removal should only be performed by professionals experienced in working with animals, and it may not be suitable for rats due to their small size and potential skin sensitivity.
There can be other alternatives to keep the device securely attached to the rats throughout the experiment:
(P.S. The above answer is generated from ChatGPT4.0. Overall, it might be best to ask the veterinarian at your institute regarding this issue. We have also conducted surgeries on mice heads but never attached any device to the hairless scalp. I hope your problems are resolved soon.)
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