I am trying to detect creatinine and I wanted to understand if there has been any study regarding any organometallic compound that has specificity for creatinine and forms a complex with it.
I don't know of organometallic compounds, but this study designed a specific detector: http://search.proquest.com/openview/ec7fef7110dc6ef28a4c1a24864cfc56/1?pq-origsite=gscholar
I have not gone through the cited references, may be they have given better answers to your question. However i will answer your question around the logic that creatinine (2-Amino-1-methyl-5H-imidazol-4-one) in its stable tautomeric form has an amine group attached to 5 membered ring which is an excellent ligand to most transition metals especially copper(II) and cobalt(III). so a copper(II) fragment can selectively bind to the creatinine with a significant thermochemistry. Some literature references for copper complexes of creatinine are as under:
DOI: 10.1016/S0277-5387(00)83797-3
http://dx.doi.org/10.1080/00958979009408216
http://dx.doi.org/10.1081/SIM-120030438
In fact the Quantification of creatinine in biological samples is also based on the pseudoenzyme activity of copper–creatinine complex see the ref.http://dx.doi.org/10.1016/j.saa.2012.02.104
The Fluorescent creatinine assay is a method of detecting creatinine in body fluids using an indicator which produces a fluorescent response when oxidized in the presence of a copperII/creatinine complex. A preferred indicator is 4-(1-methylhydrazino)-7-nitro benzooxadiazole (MNBDH) see ref.(US 6872573 B2)
Fundamentals of Urine and Body Fluid Analysis
https://books.google.co.in/books?isbn=0323277748
Nancy A. Brunzel - 2013.
In summary a copper(II) based fragment either from the above cited references or a newly designed one can do the job one such designed complex in described in the reference DOI: 10.1016/j.saa.2015.10.028 .
Thank you so much sir. I agree that copper binds to creatinine but copper also reactively binds to many biomolecules in the blood, especially albumin. Thus it cannot be used selectively for creatinine detection.