A recent research study (2015) claims that a missing link is found between brain and immune system and it has major disease links.
I have given Newspaper clippings on the same and a brief summary below:
Summary:
"In a stunning discovery that overturns decades of textbook teaching, researchers have determined that the brain is directly connected to the immune system by vessels previously thought not to exist. The discovery could have profound implications for diseases from autism to Alzheimer's to multiple sclerosis."
Thanks a lot to a reply by Dr. Emmanuelle Cugy , I provide the source for this finding as below:
Antoine Louveau, Igor Smirnov, Timothy J. Keyes, Jacob D. Eccles, Sherin J. Rouhani, J. David Peske, Noel C. Derecki, David Castle, James W. Mandell, Kevin S. Lee, Tajie H. Harris, Jonathan Kipnis. Structural and functional features of central nervous system lymphatic vessels. Nature, 2015; DOI: 10.1038/nature14432
Your views are welcome!! - Sundar
http://www.sciencedaily.com/releases/2015/06/150601122445.htm
http://www.nhs.uk/news/2015/06June/Pages/Missing-link-between-brain-and-immune-system-discovered.aspx
http://www.thehindu.com/sci-tech/science/link-between-brain-and-immune-system-found/article7291570.ece
I think the right source is :
Antoine Louveau, Igor Smirnov, Timothy J. Keyes, Jacob D. Eccles, Sherin J. Rouhani, J. David Peske, Noel C. Derecki, David Castle, James W. Mandell, Kevin S. Lee, Tajie H. Harris, Jonathan Kipnis. Structural and functional features of central nervous system lymphatic vessels. Nature, 2015; DOI: 10.1038/nature14432
Now, at last, the link is found and we can study neuro-immune interaction by asking mechanistic questions. By an innovative method of mounting the meninges of the mouse within the skullcap, so that the tissue is secured in its physiological condition, and after that dissecting it. If it was dissected first, the lymphatic vessels could not be seen, being so close to the blood vessel.
"If you don't know what you're after, you just miss it." Lymph vessels are often running close to blood vessels. 'Blood supplies nutrients and important metabolites to the cells of a tissue and collects back the waste products they produce, which requires exchange of respective constituents between the blood and tissue cells. Interstitial fluid is the fluid that occupies the spaces between the cells and constitutes their immediate environment. Water and solutes can pass between the interstitial fluid and blood via diffusion across gaps in capillary walls called intercellular clefts; thus, the blood and interstitial fluid are in dynamic equilibrium with each other. Interstitial fluid forms at the arterial (coming from the heart) end of capillaries because of the higher pressure of blood compared to veins, and most of it returns to its venous ends and venules; the rest (up to 10%) enters the lymph capillaries as lymph.'
- Badges
- Science topic