The short answer is YES (because it would be harder to prove a lack of cross-talk). However, to examine a crosstalk in a meaningful manner, one would need a simple and a robust system.
Thank you so much for your answer.. your answer gave me lot of encouragement..
I want to examine the crosstalk in a meaningful manner.. I am trying for postdoctoral fellowship... If I got that in a good lab .. then will work hard on this...