Is there any study out there where the genetic risk for IBD has been addressed in the context of a certain microbiota composition, say enterotype, or according to presence/absence of indicator species or metabolic pathways?
We have recently published that for colitis induced by T cells transferred into Rag-deficient recipients, the expression of T-bet by the T cells matters only in the context of a certain microbiota. In one type of recipients, T-bet was critical for disease and T-bet-deficient T cells were unable to induce inflammation whereas in another set of recipients T-bet-deficient T cells induced inflammation just as potently as WT T cells did.
Article The intestinal microbiota determines the colitis-inducing po...
Has anything comparable been shown for humans, e.g. that gene XYZ confers an increased risk for IBD only in the context of a Genus abc-dominated microbiota. Or the other way around, say some kind of dysbiosis predisposes an individual for IBD only in combination with a certain genetic risk factor?
There is a paper written by Wang, Yang, Chen, Yuan, Sun and Peng (2014) in World of gastroenterology that may be of interest for you.
Dear Béatrice,
thanks for your answer. A quick screening for some keywords such as "loci", "SNP", "genetic" etc. didn't really reveal an answer to my above question, so could you potentially specify which part of the review you think is relevant for my specific question?
use the key words: genetic risk for IBD and microbiota or entero* in PubMed and you get som good answers.