In other words; is there a drug or some type of treatment that people are using as a guaranteed way to maximize neurotrophin expression in any brain regions? Similar to how MECS is used as a positive control for IEG experiments.
Dear Jarret,
We found that BDNF protein level in the parietal cortex was elevated by the MPTP insult and increased further by physical exercise. Some papers:
Article Running wheel activity restores MPTP-induced deficits
Article Pre-reproductive maternal enrichment influences offspring de...
Article Novel FTY720-Based Compounds Stimulate Neurotrophin Expressi...
Article Contingent and non-contingent recreational-like exposure to ...
Dear Jarrett,
We found that treating dopaminergic cells with 160 nM FTY720 increased their expression of BDNF as noted in our 2014 ACS Med Chem Lett paper, which is cited above. I'm not certain it will work in all cells but we also see in vivo increases in neuronal BDNF in recent mouse work. This is also supported in the work of Yves Barde who showed this in a mouse model of Rett Syndrome (Deogracias et al.) http://www.ncbi.nlm.nih.gov/pubmed/22891354. Does anyone knows why BDNF levels increases in response to a toxin?
Ruth Perez
You didn't say if you were looking for a treatment in vivo, etc, or in a specific brain area. But basically a seizure or anything that enhances activity in the brain will increase the expression of BDNF on the brain areas which make this neurotrophin. Seziures are the best way to see the full capability of expression across the majority of the brain. (see C.M. Gall's work and mine as well). Hope this helps.
Julie Lauterborn
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