I'm looking for a rat oral cancer cell line to produce tumor in the oral cavity (preferably in the tongue) of healthy (immunocompetent) SD or Wistar rats. For Eg: oral squamous cell carcinoma cells.
It would be helpful if you can answer any or all of the following:
1. Do you have/know a cell line which I can use.
2. Can a cell line derived from a different strain used? For Eg: A cell line derived from Wistar rat can be used to produce tumor in SD rats?
3. Any method to transform healthy cells to tumor cells and use them for syngeneic tumor development?
4. Mention any special points / precautions to be considered to develop this type of syngeneic tumor model.
Dear Vinoth,
Check this link out:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702728/
http://link.springer.com/search?query=Animal+Models+of+Cancer+in+the+Head+and+Neck+Region&facet-content-type=%22Protocol%22
http://www.ncbi.nlm.nih.gov/pmc/?term=Animal+Models+of+Cancer+in+the+Head+and+Neck+Region
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