Is there a drug that can activate the Hippo pathway?

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What are the key theories relating to the nature and exercise of leadership?

Who are some key author to refer to?

18 May 2024 7,998 5 View

Sexual selection and speciation – unpublished data?

Dear Colleagues, We are conducting a meta-analysis to synthesize comparative studies investigating the relationship between proxies of sexual selection and species richness or speciation rate in...

07 April 2024 5,425 0 View

What can be the reason if electrode A has higher specific capacitance value than electrode B but electrode A has higher Rs value?

I have prepared two same materials with diffferent method and performed electrochemical testing. The electrode A which has higher specific capacitance gives higher (8 times) solution resistance...

25 March 2024 5,833 0 View

Which non-denaturing lysis buffer can comprehensively lyse THP-1 monocytes?

Hi, I am doing a pulldown in THP-1 wt lysate followed by MS-based proteomics. However I get a very low protein amount out of the cells (1 mg per 12 million cells). I use the following lysis...

14 February 2024 9,030 1 View

How to sovle the problem of protein sticking to Ni NTA/IDA columns after SUMO tag cleavage ?

Hi there. I have to use the pET28a-SUMO vector to get my target protein. However, I can‘t separate it from SUMO tag. My protein was about 15 Kda big and has a about 5 value of pI. Due to the...

09 January 2024 2,970 4 View

Is the cif file for MXene(Ti3C2Tx) available?

Is the cif file for MXene(Ti3C2Tx) available? If yes, can anyone provide me with one for performing rietveld refinement? I have search from COD and AMCSD website and can't seem to find one.

13 November 2023 5,000 2 View

Is spatial autocorrelation always a problem while modelling habitat suitability?

I'm wondering if you should differ between presence data of highly mobile species such as Raptors and immobile species (e.g. Plants). The dispersal of plants is limited to a certain distance, so...

23 May 2023 6,666 4 View

How to prevent sticking of single cancer cells to PDMS microfluidic chip?

I'm doing a flow experiment, flowing single MCF7 cells through PDMS microfluidic chips (connected to a glass microscope slide). Currently, I'm using a Pluronic F127 (0.1 wt%) coating. However,...

21 May 2023 9,628 3 View

Difference between power and myAUC in Seurat R package for analyzing Single Cell RNA-seq data?

I am attempting to use the Seurat FindAllMarkers function to validate markers for rice taken from the plantsSCRNA-db. I want to use the ROC test in order to get a good idea of how effective any of...

16 May 2023 2,909 1 View

Difference between power and myAUC in Seurat R package for analyzing Single Cell RNA-seq data?

I am attempting to use the Seurat FindAllMarkers function to validate markers for rice taken from the plantsSCRNA-db. I want to use the ROC test in order to get a good idea of how effective any of...

15 May 2023 6,047 0 View

How to select relevant metabolites from multiple annotations ?

I am using the Polyomics Integrated Metabolomics Pipeline (PiMP) for metabolite feature analysis. After annotating my data, I have encountered cases where multiple potential metabolites are...

24 July 2024 5,789 0 View

Is it possible to quantify activity of the non-canonical Wnt signaling pathway via transcriptional readout genes??

Hello, From my (naive) understanding, there are several target genes of the canonical Wnt signaling pathway that serve as reliable/validated transcriptional readouts of pathway activity. These...

18 June 2024 4,699 0 View

How to deal with product oscillations in the fungal chemostat?

I am operating a continuous cultivation at fixed carbon and nitrogen concentrations, and under carbon-limitation regime and varying dilution rates from 0.1 to 0.01/hr. Under these conditions all...

13 May 2024 2,510 0 View

I am looking for a biodegradation process pathway diagram by bacteria?

such as the Degradation of TNT, RDX, HMX and Nitroglycerin, it is for presentation

01 May 2024 405 3 View

What are the molecular mechanisms involved in spermatogenesis and sperm maturation?

Do these processes involve a complex interplay between molecular signaling pathways, regulation of gene expression, protein modifications, and cellular interactions? Could dysregulation of any of...

22 April 2024 9,328 3 View

What are some good in-silico methods for pathways, biomarkers, and interactions that present in diabetic microvascular complications?

The four diabetic microvascular complications I am assessing are nephropathy, neuropathy, cardiomyopathy, and retinopathy. Are there any in silico methods which can be employed to identify...

16 April 2024 1,433 0 View

Alternative to nitrogenase?

I have seen nitrogen fixation in three heterotrophs, but cannot detect any nitrogenase in their genomes. Are there any alternative pathways that I can look into that may provide information about...

01 April 2024 5,641 0 View

How to design a dose response curve for two drugs for RT-qPCR?

Hello, I am using dinitrophenol and rotenone treatments on healthy fibroblasts to study cell signalling pathways (ISR and UPR). I have chosen 1mM and 500uM based on other work but have not had...

25 March 2024 1,414 0 View

How to remove a publication I have accepted as mine by mistake?

How to remove a publication I have accepted as mine by mistake? I cannot find a deletion pathway.

24 March 2024 1,449 1 View

Biohydrogen production by different species of algae vary in their potential for biohydrogen production?

1- What are the key factors influencing the efficiency of biohydrogen production by algae? 2-How does the metabolic pathway of algae contribute to biohydrogen production and what are the potential...

02 February 2024 920 1 View