I aim to study the electrophysiological properties in pyramidal neurons in the anterior cingulate cortex (ACC) and interactions between astrocytes, interneurons, and pyramidal neurons. There is a difference between B6J and BJN in emotional behavior. I will do behavior experiments on B6N but I ask if I can do electrophysiological tests on B6J due to their availability.
I saw strong alterations in the hippocampal oscillations between these strains. Considering the impact of emotional behaviour on physiology and circuit properties, assessing behaviour in one strain and physiology in the other strain can lead to misinterpreation of your data.
Hi Gürsel,
The differences of the genetic backgrounds are important. Also, the maturation of the neurotransmitter systems may differ with age. We have previously compared the EEGs of Bl6 and Bulb-c during basal activity as well as following an epileptic trigger.
Here is the paper:
https://pubmed.ncbi.nlm.nih.gov/21964381/
Regards
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