Dear all
I am planning to activate caspase-1 and pyroptosis in skin cells without using the bacterial as stimuli. I would like to know if there is a compound that can do so and would appreciate if anyone can advise where is the source. thanks
Fadhilah
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3.
You can get certain detailed informations by following the links below:-
1. www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC)
2. www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC)
3. www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC)
UV treatment has been used to activate caspase-1 in keratinocytes.
Canonically NFkB signaling followed by treatment with the bacterial pore forming toxin Nigericin or 1-5 mM ATP has been popularly and prototypically used to activate caspase-1 and induce pyroptosis in blood-derived immune cells.
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