I know I read this in a paper detailing the rationale for work in the 1980s where platelet responses were used as model to study the effect of antidepressants and antipsychotics prior to more modern neuroscience techniques.
However, I cannot find an embryology reference that explicitly states this, unless I am misremembering what I originally read. Does anyone know of corroborating lines of enquiry or a reference to support why platelet models were used.
Platelets are derived from mesoderm. They were used as a proxy measure of 5-HT handling as they take up, store and release 5-HT - they use it for vasoconstriction and clotting. Thus one can look at drugs that target 5-HT handling - SSRIs effect on reuptake, or receptor binding assays etc. - but using platelets as a peripheral measure that is easy to sample repeatedly.
I would suspect that is due to receptor expression, rather than developmental origin, but would have to look this up.
it could be like {NSAID (antihistamines) induces drowsiness ( connection is histamine receptor blockade)}
Platelets are derived from mesoderm. They were used as a proxy measure of 5-HT handling as they take up, store and release 5-HT - they use it for vasoconstriction and clotting. Thus one can look at drugs that target 5-HT handling - SSRIs effect on reuptake, or receptor binding assays etc. - but using platelets as a peripheral measure that is easy to sample repeatedly.
Thank you. That was driving me mad, I'd obviously misread it in the original paper.
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