Dear Madusha,

The following article describes C_ON bond homolysis under mild conditions:

Perspective Alkoxyamines: a new family of pro-drugs against cancer. Concept for theranostics

Gérard Audran,a Paul Brémond,a Jean-Michel Franconi,b Sylvain R. A. Marque,*a Philippe Massot,b Philippe Mellet,bc Elodie Parzyb and Eric Thiaudièreb

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Org. Biomol. Chem., 2014,12, 719-723

DOI: 10.1039/C3OB42076K

Received 17 Oct 2013, Accepted 21 Nov 2013

First published online 12 Dec 2013

Development of anti-cancerous theranostic agents is a vivid field. This article describes a theranostic approach that relies on the triggering of cancer cell death by generation of alkyl radicals at the right place and at the right time using the presence of active proteases in the tumour environment. Alkoxyamines (R1R2NOR3) are labile molecules that homolyze into nitroxides (R1R2NO˙) and reactive alkyl radicals (R3˙). They are used as a source of active alkyl radicals for curing and nitroxides for monitoring by Overhauser-enhanced magnetic resonance imaging (OMRI). Herein, the requirements needed for applying alkoxyamines are described: (i) highly selective activation of the alkoxyamine by specific proteases; (ii) fast homolysis of the alkoxyamine C–ON bond at physiological temperature; (iii) activation of cell death processes through an increase of the local oxidative stress or potential re-activation of the immune system due to short-lived alkyl radicals; and (iv) imaging of the tumor and the drug release by sensing the nitroxide by OMRI.

http://pubs.rsc.org/en/content/articlelanding/2014/ob/c3ob42076k#!divAbstract

Hoping this will be helpful,

Rafik

Thank you sir, 

i already found that paper I am wondering whether o-propyl alkoxamines can do that ? 

Yes. For sure.