for some formulas EE% value is greater than LC%, and for some formulas EE% value is lower than LC%...is this normal???
Hi Ahmed
Entrapment efficiency gives you an idea about the %drug that is successfully entrapped/adsorbed into nanoparticles. It is calculated as follows:
%EE = [(Drug added - Free "unentrapped drug")/Drug added] *100
Example: If the %EE is 30%, it means that 30% of your drug is entrapped into the nanoparticles.
Loading capacity helps you to deal with nanoparticles after their separation from the medium and to know their drug content. It is calculated using the following equation:
%LC = [Entrapped Drug/nanoparticles weight] * 100
Example: If the loading capacity is 30%, it means that 30% of the nanoparticles weight is composed of the drug! i.e. Each 1 mg nanoparticles contains 0.3 mg drug.
Hi Ahmed
Entrapment efficiency gives you an idea about the %drug that is successfully entrapped/adsorbed into nanoparticles. It is calculated as follows:
%EE = [(Drug added - Free "unentrapped drug")/Drug added] *100
Example: If the %EE is 30%, it means that 30% of your drug is entrapped into the nanoparticles.
Loading capacity helps you to deal with nanoparticles after their separation from the medium and to know their drug content. It is calculated using the following equation:
%LC = [Entrapped Drug/nanoparticles weight] * 100
Example: If the loading capacity is 30%, it means that 30% of the nanoparticles weight is composed of the drug! i.e. Each 1 mg nanoparticles contains 0.3 mg drug.
This is exactly as Muhammad explained. Thus there is no simple relationship between EE and LC. However it is often the case that if your LC is high (meaning that the ratio between drug encapsulated and exipients is high), it will be more difficult to obtain also a high EE. But in some cases (i.e. gemcitabine squaleinyl complexes for example) both EE and LC can be high. If you try to encapsulate a lipidic drug in lipid core nanocapsules or nanoparticles the EE% can reach 100%.
There is no direct relation between EE and LC. EE is all about efficiency to entrap a drug, and LC is about content of drug. Sometimes LC is good enough, but EE depends on encapsulating material.
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