I read about the bebefits of selenium supplementation in autoimmune thyroid diseases and hypothyroidism. I am interested to know about the benefits of selenium supplementation for hyperthyroidism as well as its mechanism of action in these settings. Thank you for your feed back.
Michaela, yes proper selenium is needed for thyroid function and deficiencies in Se and Fe have been linked to hypothyroidism. Excess iodine is also a culprit in thyroid disease. Below is a link to a research paper on the impact of Fe and Se deficiency on thyroid function.
http://online.liebertpub.com/doi/pdf/10.1089/105072502761016494
Thanks Joan for the prompt reply and the link. Warnest regards, Michaela
Selenium is part of many enzymes including the deiodinases that lead to T3 from T4 in target organs. If there is hyperthyroidism might be wise to know the cause of thyroid dysfunction before making supplementation of Selenium. Best regards. Ana Crespo.
Dear Michaela, from a dermatological point of view,
Selenium and Selenoproteins are essential for proper keratinocyte function and skin development. Dietary selenium is known to protect skin against UV-induced damage and cancer and its topical application improves skin surface parameters in humans. Most important biological functions of selenium are attributed to selenoproteins, proteins containing selenium in the form of the amino acid, selenocysteine (Sec). Sec insertion into proteins depends on Sec tRNA; thus, knocking out the Sec tRNA gene (Trsp) ablates selenoprotein expression. Lack of selenoproteins in epidermal cells led to the development of hyperplastic epidermis and aberrant hair follicle morphogenesis. selenoproteins are essential antioxidants in skin and unveiled their role in keratinocyte growth and viability.
Although sodium selenit is issential for proper function of the immune system, there is no clear evidence in the literature that in HYPERthyroidism there is a role for modulating the outcome of the disease especially in multinodular goiter. In Grave's the treatment is described in textbooks however to what extent the interaction of low Selen serum level might play a role in disease induction /aggravation there is little hard data in the literature. Kind regards
selenium substitution may improve inf amatory activity in autoimmune thyroid disease but we need many investigation that it is effective in other autoimmune endocrine disease
Selenium and iodide excess has been shown to cause development of reactive oxygen species in thyroidal cells and also in thyroid hormone responsive organs. Therefore, the intricate balance between tolerable to excess must be considered for optimal functioning of thyroid gland.
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